Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937543 | 0.79 | MAPT (0.39) | KDM4EGAA | |
| SCHEMBL19937529 | 0.70 | USP2 (0.37) | GAA | |
| SCHEMBL19937527 | 0.65 | ESR1 (0.41) | KDM4EGAAOPRM1 | |
| SCHEMBL19937358 | 0.65 | ESR1 (0.41) | KDM4EOPRM1 | |
| SCHEMBL19937511 | 0.64 | MKNK1 (0.41) | — | |
| SCHEMBL19937309 | 0.64 | LMNA (0.37) | KDM4EGAAOPRM1 | |
| SCHEMBL19937483 | 0.64 | TDP1 (0.41) | OPRM1 | |
| SCHEMBL19937478 | 0.63 | ESR1 (0.38) | OPRM1 | |
| SCHEMBL19937531 | 0.62 | ESR1 (0.37) | OPRM1 | |
| SCHEMBL19937470 | 0.62 | SLC6A4 (0.58) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290427-A1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Melinta Therapeutics, Inc. (US) | 2018-03-07 | — | — | EP | disclosed |