Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937529 | 0.81 | USP2 (0.37) | GAAUSP2SMN1; SMN2DPP4 | |
| SCHEMBL19937456 | 0.79 | KDM4E (0.32) | KDM4EGAA | |
| SCHEMBL15628607 | 0.78 | ALDH1A1 (0.38) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL15628457 | 0.77 | ALDH1A1 (0.40) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL19937358 | 0.75 | ESR1 (0.41) | MAPTALDH1A1KDM4EALOX15HIF1A | |
| SCHEMBL19937527 | 0.75 | ESR1 (0.41) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL19937483 | 0.74 | TDP1 (0.41) | MAPTALDH1A1TP53ALOX15L3MBTL1 | |
| SCHEMBL19937478 | 0.72 | ESR1 (0.38) | MAPTALOX15TDP1LMNA | |
| SCHEMBL14703927 | 0.72 | ALDH1A1 (0.51) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL26039679 | 0.72 | ALDH1A1 (0.47) | MAPTALDH1A1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290427-A1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Melinta Therapeutics, Inc. (US) | 2018-03-07 | — | — | EP | disclosed |