Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937837 | 0.86 | ALDH1A1 (0.49) | ALDH1A1HTTGAAL3MBTL1KDM4E | |
| Hydrochloric Acid SCHEMBL29813270 | 0.81 | ALDH1A1 (0.60) | ALDH1A1HTTGAAKDM4EHSD11B1 | |
| SCHEMBL14200003 | 0.79 | CYP2C9 (0.41) | ALDH1A1HTTGAAKDM4EMAPT | |
| SCHEMBL15726858 | 0.79 | ALDH1A1 (0.45) | ALDH1A1HTTGAAL3MBTL1KDM4E | |
| SCHEMBL382856 | 0.79 | RBP4 (0.58) | ALDH1A1HTTGAAL3MBTL1MAPT | |
| SCHEMBL2098528 | 0.77 | RBP4 (0.57) | ALDH1A1HTTGAAL3MBTL1KDM4E | |
| SCHEMBL19154820 | 0.75 | ALDH1A1 (0.41) | ALDH1A1HTTGAAKDM4EMAPT | |
| SCHEMBL5715714 | 0.75 | ALDH1A1 (0.61) | ALDH1A1HTTGAAL3MBTL1KDM4E | |
| SCHEMBL382827 | 0.75 | RBP4 (0.39) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL1858942 | 0.75 | ALDH1A1 (0.64) | ALDH1A1HTTGAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577374-B2 | Bruton's tyrosine kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2020-03-03 | — | — | US | disclosed |
| US-20180065974-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2018-03-08 | — | — | US | disclosed |
| US-20180065974-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10577374-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | ALDH1A1 4783/4885HTT 3688/4885GAA 1670/4885 |
| US-20180065974-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BTK, ABL1, SYK | ALDH1A1 4783/4885HTT 3688/4885GAA 1670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.