Sugi Predict

Sugi Predict / Compounds / SCHEMBL1993840

SCHEMBL1993840

SCHEMBL1993840

N#Cc1ccc(C(N)=O)cn1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRM5 P41594 1/20 0.58
▸ NNMT P40261 4/20 0.55
▸ SMN1; SMN2 Q16637 1/20 0.55
▸ MYC P01106 1/20 0.53
▸ PARP15 Q460N3 2/20 0.47
▸ PARP10 Q53GL7 2/20 0.47
▸ PARP2 Q9UGN5 1/20 0.47
▸ KDM4E B2RXH2 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ KCNQ3 O43525 1/20 0.46
▸ KCNQ2 O43526 1/20 0.46
▸ F7 P08709 1/20 0.41
▸ F3 P13726 1/20 0.41
▸ SARM1 Q6SZW1 1/20 0.41
▸ SIRT2 Q8IXJ6 1/20 0.41
▸ SIRT6 Q8N6T7 1/20 0.41
▸ SIRT1 Q96EB6 1/20 0.41
▸ SIRT3 Q9NTG7 1/20 0.41
▸ SIRT5 Q9NXA8 1/20 0.41
▸ SIRT4 Q9Y6E7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19580190 0.85 KCNQ3 (0.46) GRM5NNMTSMN1; SMN2MYCPARP15
SCHEMBL4756340 0.82 GRM5 (0.60) GRM5NNMTSMN1; SMN2MYCKDM4E
SCHEMBL65165 0.82 P4HA1 (0.55) GRM5KCNQ3KCNQ2ALDH1A1MKNK2
SCHEMBL31281693 0.82 P4HA1 (0.55) GRM5KCNQ3KCNQ2ALDH1A1MKNK2
SCHEMBL4271680 0.82 GRM5 (0.60) GRM5NNMTSMN1; SMN2MYCKDM4E
SCHEMBL3868436 0.81 KCNQ3 (0.46) GRM5MYCKCNQ3KCNQ2
SCHEMBL1584376 0.81 MAPT (0.49) GRM5MYCL3MBTL1KCNQ3KCNQ2
SCHEMBL9908944 0.81 UBE2T (0.45) GRM5KCNQ3KCNQ2
SCHEMBL2515153 0.81 KCNQ3 (0.46) GRM5MYCKCNQ3KCNQ2MKNK2
Proline SCHEMBL8809342 0.79 GRM5 (0.43) GRM5NNMTSMN1; SMN2MYCPARP15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 — — EP claimed
US-20250092040-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2025-03-20 — — US disclosed
US-20240239797-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2024-07-18 — — US disclosed
US-11999730-B1 AKT1 modulators ALTEROME THERAPEUTICS, INC. (US) 2024-06-04 — — US disclosed
US-20240174667-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2024-05-30 — — US disclosed
WO-2024028243-A1 PYRAZOLO PESTICIDAL COMPOUNDS BASF SE (DE) 2024-02-08 — — WO disclosed
US-11697636-B2 Substituted benzamides HOFFMANN-LA ROCHE INC. (US) 2023-07-11 — — US disclosed
EP-3187490-B1 SUBSTITUTED BENZAMIDE DERIVATIVES HOFFMANN LA ROCHE (CH) 2022-04-06 — — EP disclosed
US-20210061760-A1 SUBSTITUTED BENZAMIDES HOFFMANN LA ROCHE (US) 2021-03-04 — — US disclosed
US-20200048194-A1 SUBSTITUTED BENZAMIDES F. HOFFMANN-LA ROCHE AG (CH) 2020-02-13 — — US disclosed
US-20060211636-A1 Macrolide Antibiotics ALIHODZIC SULEJMAN 2006-09-21 — — US disclosed
US-20050215495-A1 Macrolide antibiotics ALIHODZIC SULEJMAN 2005-09-29 — — US disclosed
US-20040077557-A1 Macrolide antibiotics GLAXO GROUP LIMITED (GB) 2004-04-22 — — US disclosed
EP-1363925-A1 MACROLIDE ANTIBIOTICS GLAXO GROUP LIMITED (GB) 2003-11-26 — — EP disclosed
WO-2002050091-A1 MACROLIDE ANTIBIOTICS GLAXO GROUP LIMITED (GB) 2002-06-27 — — WO disclosed
US-5932567-A Thrombin inhibitors BASF AKTIENGESELLSCHAFT (DE) 1999-08-03 — — US disclosed
EP-0632019-B1 Acylureas ZENECA LTD (GB) 1997-09-24 — — EP disclosed
WO-1996025426-A9 NOVEL DIPEPTIDE AMIDINES AS THROMBIN INHIBITORS — 1997-06-12 — — WO disclosed
US-5576334-A ANTICOAGULANTS ZENECA LIMITED (GB) 1996-11-19 — — US disclosed
EP-0632019-A1 Acylureas ZENECA LIMITED (GB) 1995-01-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239797-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 GRM5 3624/4885NNMT 1489/4885SMN1; SMN2 2237/4885
US-20050215495-A1 Macrolide antibiotics IL1R1, MRPL12, RPS21 GRM5 4811/4885NNMT 4578/4885SMN1; SMN2 3554/4885
US-20210061760-A1 SUBSTITUTED BENZAMIDES TAAR1, TAAR5, NPY1R GRM5 555/4885NNMT 1716/4885SMN1; SMN2 1965/4885
US-20060211636-A1 Macrolide Antibiotics IL1R1, MRPL12, RPS21 GRM5 4811/4885NNMT 4578/4885SMN1; SMN2 3554/4885
US-20200048194-A1 SUBSTITUTED BENZAMIDES TAAR1, TAAR5, NPY1R GRM5 555/4885NNMT 1716/4885SMN1; SMN2 1965/4885
US-20040077557-A1 Macrolide antibiotics MALT1, MRPL21, IL1R1 GRM5 4816/4885NNMT 4522/4885SMN1; SMN2 3041/4885
US-11697636-B2 Substituted benzamides TAAR1, TAAR5, NPY1R GRM5 555/4885NNMT 1716/4885SMN1; SMN2 1965/4885
US-20250092040-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 GRM5 3624/4885NNMT 1489/4885SMN1; SMN2 2237/4885
US-11999730-B1 AKT1 modulators AKT1S1, AKT1, AKT2 GRM5 3624/4885NNMT 1489/4885SMN1; SMN2 2237/4885
US-20240174667-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 GRM5 3624/4885NNMT 1489/4885SMN1; SMN2 2237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.