Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.45 |
| ▸ | PKM | P14618 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28526187 | 0.91 | MAPT (0.49) | MAPTPKMPOLBTDP1LMNA | |
| SCHEMBL29482091 | 0.87 | MAPT (0.53) | MAPTPKMPOLBTDP1LMNA | |
| SCHEMBL1699995 | 0.87 | MAPT (0.53) | MAPTPKMPOLBTDP1LMNA | |
| SCHEMBL29750126 | 0.83 | BCL2L1 (0.54) | — | |
| SCHEMBL22581515 | 0.83 | MAPT (0.54) | MAPTPKMPOLBTDP1LMNA | |
| SCHEMBL29482090 | 0.83 | MAPT (0.54) | MAPTPKMPOLBTDP1LMNA | |
| SCHEMBL29034670 | 0.82 | MAPT (0.52) | MAPTPKMPOLBTDP1LMNA | |
| SCHEMBL16038895 | 0.82 | MAPT (0.54) | MAPTPKMPOLBTDP1LMNA | |
| SCHEMBL1700226 | 0.81 | LMNA (0.48) | MAPTPOLBLMNAKMT2AMEN1 | |
| SCHEMBL30467963 | 0.81 | LMNA (0.48) | MAPTPOLBLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641897-B | Bcl-2 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-109293656-A | Bcl-2 selective depressant and its preparation and use | 北京赛林泰医药技术有限公司 | 2019-02-01 | — | — | CN | disclosed |
| WO-2018041248-A1 | BCL-2 SELECTIVE INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2018-03-08 | — | — | WO | disclosed |