Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 17/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17001527 | 0.83 | P2RX7 (0.54) | P2RX7 | |
| SCHEMBL16995066 | 0.81 | P2RX7 (0.56) | DPP4P2RX7 | |
| SCHEMBL17001577 | 0.80 | P2RX7 (0.51) | DPP4P2RX7 | |
| SCHEMBL19940615 | 0.76 | ALDH1A1 (0.43) | P2RX7 | |
| SCHEMBL15129234 | 0.72 | P2RX7 (0.48) | DPP4P2RX7 | |
| SCHEMBL16995121 | 0.71 | P2RX7 (0.47) | DPP4P2RX7 | |
| SCHEMBL16995067 | 0.71 | DPP4 (0.46) | DPP4P2RX7 | |
| SCHEMBL16461271 | 0.69 | P2RX7 (0.54) | DPP4P2RX7 | |
| SCHEMBL15797470 | 0.69 | P2RX7 (0.52) | DPP4P2RX7 | |
| SCHEMBL24522590 | 0.68 | P2RX7 (0.41) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290417-A1 | 2-CHLORO-N-[2-(1,3-THIAZOL-5-YL)ETHYL]-5-(5-FLUOROPYRIMIDIN-2-YL)-BENZAMIDES AND THEIR USE AS P2X7 RECEPTOR ANTAGONISTS | AXXAM S.p.A. (IT) | 2018-03-07 | — | — | EP | disclosed |