SCHEMBL19940834

SCHEMBL19940834

C#CC(c1ccc(Cl)cc1F)C1CCN(S(=O)(=O)c2c(C)n[nH]c2C)CC1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PROKR1 Q8TCW9 20/20 0.83
FPR2 P25090 17/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15548712 0.91 PROKR1 (1.00) PROKR1FPR2
SCHEMBL19940835 0.80 PROKR1 (0.54) PROKR1FPR2
SCHEMBL15536282 0.77 PROKR1 (1.00) PROKR1FPR2
SCHEMBL15548951 0.77 PROKR1 (1.00) PROKR1FPR2
SCHEMBL15548246 0.77 PROKR1 (1.00) PROKR1FPR2
SCHEMBL15549033 0.76 FPR2 (1.00) PROKR1FPR2
SCHEMBL15537136 0.76 PROKR1 (1.00) PROKR1FPR2
SCHEMBL15548651 0.74 PROKR1 (1.00) PROKR1FPR2
SCHEMBL15549273 0.74 FPR2 (1.00) PROKR1FPR2
SCHEMBL15549168 0.73 FPR2 (1.00) PROKR1FPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855449-B1 SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES TAKEDA PHARMACEUTICALS CO (JP) 2018-03-07 EP disclosed