Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.52 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30076252 | 0.81 | PDCD1 (0.45) | PDCD1CD274KDRCYP11B2ABL1 | |
| SCHEMBL19713024 | 0.81 | PDCD1 (0.45) | PDCD1CD274KDRCYP11B2ABL1 | |
| SCHEMBL8312915 | 0.78 | CCR4 (0.55) | CCR4TP53TRPV1MEN1USP2 | |
| SCHEMBL24312500 | 0.75 | CCR4 (0.38) | PDCD1CD274CCR4KDRJAK2 | |
| SCHEMBL18979729 | 0.71 | PDCD1 (0.73) | PDCD1CD274 | |
| SCHEMBL19897441 | 0.71 | PDCD1 (0.74) | PDCD1CD274KDRTRPV1 | |
| SCHEMBL19897446 | 0.71 | PDCD1 (1.00) | PDCD1CD274KDRABL1TRPV1 | |
| SCHEMBL15808426 | 0.70 | IMPDH2 (0.43) | CCR4TP53CYP11B2 | |
| SCHEMBL29282135 | 0.69 | KDR (0.41) | PDCD1CD274CCR4KDRJAK2 | |
| SCHEMBL31130330 | 0.67 | CCR4 (0.50) | CCR4KDRTP53TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504198-B1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORP (US) | 2023-01-25 | — | — | EP | disclosed |
| EP-3943083-A1 | SMALL-MOLECULE INHIBITOR OF PD-1/PD-L1, PHARMACEUTICAL COMPOSITION THEREOF WITH PD-L1 ANTIBODY, AND APPLICATION OF SAME | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. (CN) | 2022-01-26 | — | — | EP | disclosed |
| WO-2018044783-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-03-08 | — | — | WO | disclosed |