Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19945973 | 0.78 | KMT2A (0.40) | CCR3MAPTHTTNPSR1KMT2A | |
| SCHEMBL500100 | 0.77 | SMN1; SMN2 (0.39) | CCR3MAPTKMT2AMEN1NPC1 | |
| SCHEMBL17429759 | 0.77 | SMN1; SMN2 (0.39) | CCR3MAPTKMT2AMEN1NPC1 | |
| SCHEMBL468070 | 0.75 | KMT2A (0.58) | CCR3HTTKMT2AMEN1NPC1 | |
| SCHEMBL683522 | 0.75 | KMT2A (0.58) | CCR3HTTKMT2AMEN1NPC1 | |
| SCHEMBL10256756 | 0.73 | CCR3 (0.45) | CCR3MAPTKMT2AMEN1NPC1 | |
| SCHEMBL15990731 | 0.72 | ALDH1A1 (0.38) | MAPTHTTNPC1ALDH1A1 | |
| SCHEMBL8587260 | 0.72 | CCR3 (0.44) | CCR3MAPTKMT2AMEN1NPC1 | |
| SCHEMBL1287146 | 0.71 | OPRM1 (0.52) | HTTKMT2AMEN1SMN1; SMN2OPRM1 | |
| SCHEMBL9269920 | 0.67 | ANPEP (0.49) | MAPTHTTNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3293182-A1 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE | Aerpio Therapeutics, Inc. (US) | 2018-03-14 | — | — | EP | disclosed |