Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5925932 | 0.67 | GPR84 (0.48) | AXLCDK8GPR84PIK3CDPIK3CA | |
| SCHEMBL297772 | 0.65 | CDK8 (0.55) | AXLCDK8PIK3CDPIK3CAPIK3CB | |
| SCHEMBL1564169 | 0.65 | AXL (0.36) | AXLCDK8GPR84PIK3CDPIK3CA | |
| SCHEMBL29725317 | 0.64 | GPR84 (0.45) | AXLCDK8GPR84PIK3CDPIK3CA | |
| SCHEMBL9288889 | 0.64 | GPR84 (0.45) | AXLCDK8GPR84PIK3CDPIK3CA | |
| SCHEMBL23147918 | 0.64 | AXL (0.37) | AXLCDK8GPR84PIK3CDPIK3CA | |
| SCHEMBL16621143 | 0.64 | GPR84 (0.45) | AXLCDK8GPR84PIK3CDPIK3CA | |
| SCHEMBL1565089 | 0.64 | AXL (0.41) | AXLCDK8GPR84PIK3CDPIK3CA | |
| SCHEMBL21178411 | 0.64 | GPR84 (0.45) | AXLCDK8GPR84PIK3CDPIK3CA | |
| SCHEMBL24005643 | 0.64 | AXL (0.37) | AXLCDK8GPR84PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111747952-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-10-09 | — | — | CN | claimed |
| CN-111689963-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-09-22 | — | — | CN | claimed |
| US-20180072715-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-15 | — | — | US | claimed |
| US-20230203034-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2023-06-29 | — | — | US | disclosed |
| US-11608338-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | MERCK PATENT GMBH (DE) | 2023-03-21 | — | — | US | disclosed |
| US-20210198257-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2021-07-01 | — | — | US | disclosed |
| US-10975075-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | MERCK PATENT GMBH (DE) | 2021-04-13 | — | — | US | disclosed |
| US-20200325137-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2020-10-15 | — | — | US | disclosed |
| US-10745399-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | MERCK PATENT GMBH (DE) | 2020-08-18 | — | — | US | disclosed |
| EP-3560924-A1 | IMIDAZOLONYL QUINOLINES AND THEIR USE AS ATM KINASE INHIBITORS | Merck Patent GmbH (DE) | 2019-10-30 | — | — | EP | disclosed |
| US-10457677-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | MERCK PATENT GMBH (DE) | 2019-10-29 | — | — | US | disclosed |
| US-20190211013-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2019-07-11 | — | — | US | disclosed |
| US-20180072715-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203034-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | ATM, CHEK2, CHEK1 | AXL 1970/4885CDK8 377/4885GPR84 2562/4885 |
| US-20190211013-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | ATM, CHEK2, CHEK1 | AXL 1970/4885CDK8 377/4885GPR84 2562/4885 |
| US-10457677-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | ATM, CHEK2, CHEK1 | AXL 1102/4885CDK8 401/4885GPR84 3488/4885 |
| US-10975075-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | ATM, CHEK2, CHEK1 | AXL 661/4885CDK8 509/4885GPR84 3755/4885 |
| US-20210198257-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | ATM, CHEK2, CHEK1 | AXL 1970/4885CDK8 377/4885GPR84 2562/4885 |
| US-10745399-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | ATM, CHEK2, CHEK1 | AXL 881/4885CDK8 294/4885GPR84 3770/4885 |
| US-20200325137-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | ATM, CHEK2, CHEK1 | AXL 1970/4885CDK8 377/4885GPR84 2562/4885 |
| US-11608338-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | ATM, CHEK2, CHEK1 | AXL 1970/4885CDK8 377/4885GPR84 2562/4885 |
| US-20180072715-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | ATM, CHEK2, CHEK1 | AXL 1102/4885CDK8 401/4885GPR84 3488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.