Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11286572 | 0.79 | AXL (0.39) | AXLCDK8FGFR1KDRPRKD3 | |
| SCHEMBL5925932 | 0.79 | GPR84 (0.48) | AXLCDK8BTKGPR84PIK3CA | |
| SCHEMBL1565089 | 0.76 | AXL (0.41) | AXLCDK8FGFR1KDRGPR84 | |
| SCHEMBL18012904 | 0.76 | GPR84 (0.45) | AXLCDK8FGFR1KDRAURKA | |
| SCHEMBL23147918 | 0.76 | AXL (0.37) | AXLCDK8GPR84PIK3CAPIK3CD | |
| SCHEMBL24005741 | 0.76 | RIPK1 (0.42) | AXLCDK8FGFR1KDRPRKD3 | |
| SCHEMBL9887640 | 0.76 | AXL (0.42) | AXLCDK8FGFR1KDRPRKD3 | |
| SCHEMBL20783135 | 0.76 | CDK8 (0.34) | AXLCDK8FGFR1KDRPRKD3 | |
| SCHEMBL25613026 | 0.76 | FEN1 (0.42) | AXLCDK8FGFR1KDRGPR84 | |
| SCHEMBL24005535 | 0.73 | BRD4 (0.43) | AXLCDK8FGFR1KDRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4227311-A1 | CONDENSED HETEROCYCLIC DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC DISEASES | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2023-08-16 | — | — | EP | disclosed |
| WO-2023078398-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021223736-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2021-11-11 | — | — | WO | disclosed |