Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19949437 | 0.84 | ALDH1A1 (0.38) | GAACTSKALDH1A1KDM4EHPGD | |
| SCHEMBL19949458 | 0.82 | GAA (0.37) | GAACTSKALDH1A1KDM4EHPGD | |
| SCHEMBL19949449 | 0.75 | ATR (0.45) | ALDH1A1KDM4EHSD17B10KCNA5KCNH2 | |
| SCHEMBL19949436 | 0.71 | ALDH1A1 (0.36) | GAACTSKALDH1A1KDM4EHPGD | |
| SCHEMBL16272261 | 0.71 | KCNA5 (0.45) | GAAALDH1A1KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL4929760 | 0.70 | TSHR (0.40) | ALDH1A1HSD17B10LMNASMN1; SMN2KCNA5 | |
| SCHEMBL2711245 | 0.68 | KDM4E (0.43) | GAACTSKALDH1A1KDM4EHPGD | |
| SCHEMBL6071989 | 0.67 | HTT (0.44) | GAACTSKALDH1A1KDM4EHPGD | |
| SCHEMBL7745378 | 0.66 | DPP4 (0.46) | ALDH1A1LMNASMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL8872297 | 0.65 | CHRM2 (0.40) | MEN1KMT2AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10538491-B2 | 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators | VANDERBILT UNIVERSITY (US) | 2020-01-21 | — | — | US | disclosed |
| US-20180072674-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10538491-B2 | 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators | GRM2, GRIA2, GRIN2A | GAA 3835/4885CTSK 4694/4885ALDH1A1 3137/4885 |
| US-20180072674-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | GRM2, GRM1, GRIN2A | GAA 2565/4885CTSK 4001/4885ALDH1A1 4190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.