Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27799123 | 0.78 | KDM4E (0.45) | KDM4ELMNAROCK2ROCK1CDC42BPB | |
| SCHEMBL2145134 | 0.76 | LRRK2 (0.42) | KDM4ELMNAROCK2ROCK1ALDH1A1 | |
| SCHEMBL19949458 | 0.73 | GAA (0.37) | KDM4ELMNAROCK2ROCK1CDC42BPB | |
| SCHEMBL6595642 | 0.72 | KDM4E (0.51) | KDM4ELMNAALDH1A1HPGDL3MBTL1 | |
| SCHEMBL2084217 | 0.72 | ALDH1A1 (0.51) | KDM4ELMNAROCK2ROCK1CDC42BPB | |
| SCHEMBL19949436 | 0.71 | ALDH1A1 (0.36) | KDM4ELMNAROCK2ROCK1CDC42BPB | |
| SCHEMBL2713859 | 0.70 | LGMN (0.43) | KDM4ELMNAALDH1A1HPGDCTSK | |
| SCHEMBL30622679 | 0.69 | KDM4E (0.57) | KDM4ELMNAALDH1A1L3MBTL1CTSK | |
| SCHEMBL17583342 | 0.69 | KDM4E (0.57) | KDM4ELMNAALDH1A1L3MBTL1CTSK | |
| SCHEMBL19949459 | 0.68 | GAA (0.37) | KDM4ELMNAROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445886-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151791-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |