Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.54 |
| ▸ | SLC1A2 | P43004 | 7/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 7/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 10/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 8/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.39 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.39 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | BHMT | Q93088 | 1/20 | 0.38 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18762560 | 1.00 | SLC7A5 (0.54) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL3967004 | 0.82 | SLC7A5 (0.56) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL3623646 | 0.82 | SLC7A5 (0.56) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| Hydrochloric Acid SCHEMBL21518209 | 0.80 | SLC7A5 (0.54) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL2422005 | 0.79 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL2422006 | 0.79 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL3514273 | 0.79 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL8015345 | 0.79 | SLC7A5 (0.62) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL76553 | 0.78 | PTGS1 (0.46) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL4533762 | 0.78 | PTGS1 (0.46) | SLC7A5SLC1A2SLC1A1SLC1A3GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190359653-A1 | SELECTIVE PEPTIDE INHIBITORS OF FRIZZLED | GENENTECH INC (US) | 2019-11-28 | — | — | US | disclosed |
| EP-3509616-A1 | SELECTIVE PEPTIDE INHIBITORS OF FRIZZLED | H. Hoffnabb-La Roche Ag (CH) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018049275-A1 | SELECTIVE PEPTIDE INHIBITORS OF FRIZZLED | GENENTECH, INC. (US) | 2018-03-15 | — | — | WO | disclosed |