Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16268674 | 0.79 | KDM4E (0.54) | POLQKDM4EALDH1A1TDP1ATM | |
| SCHEMBL5423901 | 0.78 | NR1H2 (0.48) | POLQGAAACHESLC6A2SLC6A4 | |
| SCHEMBL12831776 | 0.78 | SLC6A4 (0.50) | POLQACHESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11824058 | 0.75 | AKR1B1 (0.53) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL16293742 | 0.75 | RIPK1 (0.43) | POLQKDM4EALDH1A1 | |
| SCHEMBL16269271 | 0.75 | POLQ (0.46) | POLQKDM4EALDH1A1TDP1ATM | |
| SCHEMBL16269092 | 0.74 | ACKR3 (0.51) | POLQACHEMAOAMAOB | |
| SCHEMBL20494540 | 0.74 | NPC1 (0.46) | KDM4EALDH1A1ATMMEN1KMT2A | |
| SCHEMBL22651953 | 0.74 | SLC6A2 (0.48) | POLQKDM4EALDH1A1TDP1ATM | |
| SCHEMBL322185 | 0.74 | NPC1 (0.46) | KDM4EALDH1A1ATMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049152-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |