Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9239478 | 0.79 | CRBN (0.37) | CRBNDDB1IKZF3 | |
| SCHEMBL6232358 | 0.79 | CRBN (0.33) | CRBNDDB1IKZF3 | |
| SCHEMBL15703044 | 0.75 | DDB1 (0.36) | CRBNDDB1POLB | |
| SCHEMBL33371399 | 0.69 | CRBN (0.33) | CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL68773 | 0.69 | CRBN (0.33) | CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL7099066 | 0.68 | CRBN (0.33) | CRBNDDB1IKZF3 | |
| SCHEMBL2974249 | 0.67 | CRBN (0.32) | CRBNDDB1IKZF3ESR2 | |
| SCHEMBL9055828 | 0.66 | CRBN (0.37) | CRBNDDB1IKZF3ESR2ALDH1A1 | |
| SCHEMBL15237823 | 0.66 | — | — | |
| SCHEMBL9731788 | 0.62 | MAPT (0.34) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512241-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGIC DISORDERS | Neurop, Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075537-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGIC DISORDERS | NEUROP, INC. (US) | 2011-06-23 | — | — | WO | disclosed |