Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.32 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473611 | 0.79 | CRBN (0.32) | CRBNDDB1 | |
| SCHEMBL9055828 | 0.72 | CRBN (0.37) | CRBNDDB1IKZF3ESR2 | |
| SCHEMBL68773 | 0.68 | CRBN (0.33) | CRBNDDB1IKZF3 | |
| SCHEMBL33371399 | 0.68 | CRBN (0.33) | CRBNDDB1IKZF3 | |
| SCHEMBL7985487 | 0.67 | CRBN (0.33) | CRBNDDB1IKZF3 | |
| SCHEMBL1995236 | 0.67 | CRBN (0.36) | CRBNDDB1IKZF3ESR2 | |
| SCHEMBL4804572 | 0.66 | MAPT (0.35) | CRBNDDB1IKZF3 | |
| SCHEMBL9731788 | 0.64 | MAPT (0.34) | CRBNDDB1 | |
| SCHEMBL7098448 | 0.63 | CRBN (0.36) | CRBNDDB1 | |
| SCHEMBL5946816 | 0.62 | DDB1 (0.32) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777039-B2 | Process for the preparation of aripiprazole | ALEMBIC LIMITED (IN) | 2010-08-17 | — | — | US | claimed |
| US-7361756-B2 | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-04-22 | — | — | US | claimed |
| WO-2007113846-A1 | A PROCESS FOR THE PREPARATION OF ARIPIPRAZOLE | ALEMBIC LIMITED (IN) | 2007-10-11 | — | — | WO | claimed |
| EP-1765782-A1 | METHOD OF MAKING 7-(4-BROMOBUTOXY)-3,4-DIHYDROCARBOSTYRIL | Teva Pharmaceutical Industries Ltd (IL) | 2007-03-28 | — | — | EP | claimed |
| US-20060258869-A1 | Process for the preparation of aripiprazole | ALEMBIC LIMITED (IN) | 2006-11-16 | — | — | US | claimed |
| WO-2006001846-A1 | METHOD OF MAKING 7-(4-BROMOBUTOXY)-3,4-DIHYDROCARBOSTYRIL | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-01-05 | — | — | WO | claimed |
| US-20050215585-A1 | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-09-29 | — | — | US | claimed |
| US-7777039-B2 | Process for the preparation of aripiprazole | ALEMBIC LIMITED (IN) | 2010-08-17 | — | — | US | disclosed |
| US-7777039-B2 | Process for the preparation of aripiprazole | ALEMBIC LIMITED (IN) | 2010-08-17 | — | — | US | disclosed |
| EP-1984352-A1 | A NOVEL PROCESS FOR PREPARATION OF ARIPIPRAZOLE AND ITS INTERMEDIATES | UNICHEM LABORATORIES LIMITED (IN) | 2008-10-29 | — | — | EP | disclosed |
| US-7361756-B2 | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-04-22 | — | — | US | disclosed |
| US-7361756-B2 | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-04-22 | — | — | US | disclosed |
| WO-2007148191-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ARIPIPRAZOLE | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2007-12-27 | — | — | WO | disclosed |
| US-20060258869-A1 | Process for the preparation of aripiprazole | ALEMBIC LIMITED (IN) | 2006-11-16 | — | — | US | disclosed |
| WO-2006001846-A1 | METHOD OF MAKING 7-(4-BROMOBUTOXY)-3,4-DIHYDROCARBOSTYRIL | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-01-05 | — | — | WO | disclosed |
| WO-2006001846-A1 | METHOD OF MAKING 7-(4-BROMOBUTOXY)-3,4-DIHYDROCARBOSTYRIL | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-01-05 | — | — | WO | disclosed |
| US-20050215585-A1 | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-09-29 | — | — | US | disclosed |
| US-20050215585-A1 | Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-09-29 | — | — | US | disclosed |
| US-6514991-B2 | Treating metabolic disorders mediated by insulin resistance or hyperglycemia; treating or inhibiting type 11 diabetes or urinary incontinence; increasing the lean meat to fat ratio in a mammal | WYETH | 2003-02-04 | — | — | US | disclosed |
| US-20020068751-A1 | Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068751-A1 | Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | CRBN 3362/4885DDB1 2630/4885IKZF3 2888/4885 |
| US-20060258869-A1 | Process for the preparation of aripiprazole | CYP2F1, CYP3A4, CYP2A7 | CRBN 604/4885DDB1 3783/4885IKZF3 3491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.