Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17847704 | 0.76 | ATM (0.39) | — | |
| SCHEMBL5668728 | 0.66 | PTGS1 (0.41) | PTGS1PTGS2ALOX5 | |
| SCHEMBL10767082 | 0.66 | BRD4 (0.41) | — | |
| SCHEMBL7236903 | 0.66 | MAPK13 (0.62) | ALOX5RECQL | |
| SCHEMBL28207617 | 0.65 | SLC18A3 (0.37) | — | |
| SCHEMBL6613526 | 0.65 | ESR2 (0.39) | — | |
| SCHEMBL6610340 | 0.64 | MAOA (0.57) | PTGS1PTGS2 | |
| SCHEMBL9340634 | 0.64 | BRD4 (0.42) | RECQL | |
| SCHEMBL9358742 | 0.63 | MAPT (0.44) | — | |
| SCHEMBL26640860 | 0.63 | MAPT (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049008-A1 | DASH INHIBITORS, AND USES RELATED THERETO | TRUSTEES OF TUFTS COLLEGE (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018049015-A1 | COMBINATION THERAPIES USING IMMUNO-DASH INHIBITORS AND PD-1 ANTAGONISTS | TRUSTEES OF TUFTS COLLEGE (US) | 2018-03-15 | — | — | WO | disclosed |