Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | F9 | P00740 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19964840 | 0.84 | KDM4E (0.48) | FGFR1KDM4EALDH1A1ORAI1F9 | |
| SCHEMBL17531414 | 0.83 | FGFR1 (0.58) | FGFR1KDM4EALDH1A1ORAI1F9 | |
| SCHEMBL19964835 | 0.82 | ORAI1 (0.46) | FGFR1KDM4EALDH1A1ORAI1F9 | |
| SCHEMBL17531409 | 0.78 | FGFR1 (0.57) | FGFR1ALDH1A1ORAI1NPC1RAB9A | |
| SCHEMBL16147899 | 0.77 | MEN1 (0.58) | FGFR1ORAI1F9F10NPC1 | |
| SCHEMBL16158476 | 0.76 | FGFR1 (0.61) | FGFR1ORAI1F9F10NPC1 | |
| SCHEMBL23680588 | 0.74 | HPGD (0.62) | FGFR1ALDH1A1 | |
| SCHEMBL16158509 | 0.73 | FGFR1 (0.57) | FGFR1NPC1RAB9AKDRAURKA | |
| SCHEMBL19964494 | 0.73 | FLT3 (0.46) | LOXL2ALDH1A1 | |
| SCHEMBL16147819 | 0.72 | FGFR1 (0.70) | FGFR1ALDH1A1ORAI1F9F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | claimed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |