Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17531414 | 0.86 | FGFR1 (0.58) | KDM4EALDH1A1ORAI1NPC1RAB9A | |
| SCHEMBL19964835 | 0.84 | ORAI1 (0.46) | KDM4EALDH1A1ORAI1MEN1KMT2A | |
| SCHEMBL19953244 | 0.84 | LOXL2 (0.46) | KDM4EALDH1A1ORAI1NPC1RAB9A | |
| SCHEMBL17531409 | 0.80 | FGFR1 (0.57) | ALDH1A1ORAI1NPC1RAB9AFGFR1 | |
| SCHEMBL19964496 | 0.80 | IDO1 (0.48) | ALDH1A1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL16147899 | 0.80 | MEN1 (0.58) | ORAI1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL16158476 | 0.78 | FGFR1 (0.61) | ORAI1NPC1RAB9AFGFR1AURKA | |
| SCHEMBL23680588 | 0.76 | HPGD (0.62) | ALDH1A1FGFR1HPGDTP53 | |
| SCHEMBL16158509 | 0.75 | FGFR1 (0.57) | NPC1RAB9AFGFR1AURKAKDR | |
| SCHEMBL16147819 | 0.75 | FGFR1 (0.70) | ALDH1A1ORAI1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |