Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.32 |
| ▸ | AOC2 | O75106 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20542049 | 0.95 | MEN1 (0.33) | MEN1MAPK1KMT2AFOLH1CA12 | |
| SCHEMBL20271345 | 0.92 | MEN1 (0.34) | MEN1MAPK1KMT2ACA12CA14 | |
| SCHEMBL19373170 | 0.90 | FOLH1 (0.36) | MEN1MAPK1KMT2AFOLH1CA12 | |
| SCHEMBL19953443 | 0.86 | FOLH1 (0.33) | MEN1MAPK1KMT2AFOLH1CA12 | |
| SCHEMBL19953448 | 0.81 | MEN1 (0.33) | MEN1MAPK1KMT2AFOLH1CA12 | |
| SCHEMBL14476349 | 0.80 | MEN1 (0.37) | MEN1MAPK1KMT2AFOLH1CA1 | |
| SCHEMBL19966587 | 0.80 | MEN1 (0.33) | MEN1MAPK1KMT2AFOLH1DPP8 | |
| SCHEMBL19953298 | 0.79 | RORC (0.41) | AOC2MAOB | |
| SCHEMBL10239091 | 0.79 | CA12 (0.36) | MEN1MAPK1KMT2ACA12CA14 | |
| SCHEMBL23160914 | 0.78 | FOLH1 (0.34) | MEN1MAPK1KMT2AFOLH1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12202831-B2 | Small molecule inhibitors of the JAK family of kinases | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-21 | — | — | US | disclosed |
| US-20240376099-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | NOVARTIS AG (CH) | 2024-11-14 | — | — | US | disclosed |
| US-11827638-B2 | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-28 | — | — | US | disclosed |
| US-11787807-B2 | Small molecule inhibitors of the JAK family of kinases | JANSSEN PHARMACEUTICA NV (BE) | 2023-10-17 | — | — | US | disclosed |
| EP-3555096-B1 | IMIDAZOPYRROLOPYRIDINE AS INHIBITORS OF THE JAK FAMILY OF KINASES | JANSSEN PHARMACEUTICA NV (BE) | 2022-11-23 | — | — | EP | disclosed |
| EP-4086256-A1 | SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES | Janssen Pharmaceutica NV (BE) | 2022-11-09 | — | — | EP | disclosed |
| EP-4059934-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | Novartis AG (CH) | 2022-09-21 | — | — | EP | disclosed |
| EP-3555097-B1 | IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDINE COMPOUNDS AS INHIBITORS OF JANUS KINASES | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-15 | — | — | EP | disclosed |
| EP-3510033-B1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | NOVARTIS AG (CH) | 2021-11-24 | — | — | EP | disclosed |
| US-20210340144-A1 | SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-04 | — | — | US | disclosed |
| US-20190211009-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. | 2019-07-11 | — | — | US | disclosed |
| US-20190185474-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JANSSEN PHARMACEUTICA NV (BE) | 2019-06-20 | — | — | US | disclosed |
| US-20190177322-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JANSSEN PHARMACEUTICA NV (BE) | 2019-06-13 | — | — | US | disclosed |
| US-20190177321-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JANSSEN PHARMACEUTICA NV (BE) | 2019-06-13 | — | — | US | disclosed |
| US-10294226-B2 | Small molecule inhibitors of the JAK family of kinases | JANSSEN PHARMACEUTICA NV (BE) | 2019-05-21 | — | — | US | disclosed |
| US-20180170931-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-21 | — | — | US | disclosed |
| WO-2018112382-A1 | IMIDAZOPYRROLOPYRIDINE AS INHIBITORS OF THE JAK FAMILY OF KINASES | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-21 | — | — | WO | disclosed |
| WO-2018112379-A1 | SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-21 | — | — | WO | disclosed |
| WO-2018047081-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | NOVARTIS AG (CH) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018047081-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | NOVARTIS AG (CH) | 2018-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787807-B2 | Small molecule inhibitors of the JAK family of kinases | JAK2, JAK1, JAK3 | MEN1 4361/4885MAPK1 135/4885KMT2A 1012/4885 |
| US-11827638-B2 | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases | JAK1, JAK2, JAK3 | MEN1 4729/4885MAPK1 69/4885KMT2A 1510/4885 |
| US-20210340144-A1 | SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES | JAK2, JAK1, JAK3 | MEN1 4361/4885MAPK1 135/4885KMT2A 1012/4885 |
| US-20190177321-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JAK1, JAK2, JAK3 | MEN1 4625/4885MAPK1 81/4885KMT2A 1096/4885 |
| US-20240376099-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | TLR3, TLR1, TLR4 | MEN1 3998/4885MAPK1 992/4885KMT2A 3726/4885 |
| US-20190211009-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | TLR3, TLR1, TLR4 | MEN1 3998/4885MAPK1 992/4885KMT2A 3726/4885 |
| US-10294226-B2 | Small molecule inhibitors of the JAK family of kinases | JAK1, JAK2, JAK3 | MEN1 4625/4885MAPK1 81/4885KMT2A 1096/4885 |
| US-20190177322-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JAK1, JAK2, JAK3 | MEN1 4625/4885MAPK1 81/4885KMT2A 1096/4885 |
| US-12202831-B2 | Small molecule inhibitors of the JAK family of kinases | JAK1, JAK2, JAK3 | MEN1 4625/4885MAPK1 81/4885KMT2A 1096/4885 |
| US-20180170931-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JAK1, JAK2, JAK3 | MEN1 4625/4885MAPK1 81/4885KMT2A 1096/4885 |
| US-20190185474-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JAK1, JAK2, JAK3 | MEN1 4625/4885MAPK1 81/4885KMT2A 1096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.