Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 9/20 | 1.00 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211254 | 0.83 | LOXL2 (0.71) | LOXL2PRMT5WDR77CHEK1PIKFYVE | |
| Hydrochloric Acid SCHEMBL19211241 | 0.82 | LOXL2 (0.70) | LOXL2PRMT5WDR77CHEK1PIKFYVE | |
| SCHEMBL19964816 | 0.73 | LOXL2 (0.57) | LOXL2PRMT5WDR77SYK | |
| SCHEMBL29214194 | 0.73 | LRRK2 (0.70) | LOXL2CHEK1LRRK2PIM1PIM2 | |
| SCHEMBL30914585 | 0.73 | LRRK2 (0.70) | LOXL2CHEK1LRRK2PIM1PIM2 | |
| SCHEMBL16014174 | 0.73 | GSK3B (0.57) | LOXL2LRRK2PIM1AXL | |
| SCHEMBL19953274 | 0.72 | LOXL2 (0.65) | LOXL2 | |
| SCHEMBL16848369 | 0.72 | LOXL2 (0.56) | LOXL2PRMT5WDR77LRRK2PIKFYVE | |
| SCHEMBL19953414 | 0.72 | LOXL2 (0.57) | LOXL2 | |
| SCHEMBL19964757 | 0.72 | LOXL2 (1.00) | LOXL2PIK3CDPIK3CAPIK3CBPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | claimed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |