Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 9/20 | 0.65 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211328 | 0.81 | PRMT5 (0.53) | LOXL2MMP2MMP13MMP14CYP2A6 | |
| SCHEMBL31317820 | 0.79 | CYP19A1 (0.71) | MMP2MMP13MMP14CYP11B1CYP11B2 | |
| SCHEMBL21812408 | 0.79 | CYP19A1 (0.71) | MMP2MMP13MMP14CYP11B1CYP11B2 | |
| SCHEMBL19964478 | 0.79 | LOXL2 (1.00) | LOXL2CYP11B1CYP11B2IDO1 | |
| SCHEMBL28015041 | 0.77 | MMP2 (0.51) | LOXL2MMP2MMP13MMP14CYP11B1 | |
| SCHEMBL7273923 | 0.76 | AURKA (0.56) | MMP2MMP13MMP14CYP11B1CYP11B2 | |
| SCHEMBL19953219 | 0.75 | LOXL2 (0.60) | LOXL2CYP2A6CLK2DYRK1A | |
| SCHEMBL6066464 | 0.75 | LOXL2 (0.56) | LOXL2CYP2A6 | |
| SCHEMBL19953414 | 0.74 | LOXL2 (0.57) | LOXL2IDO1 | |
| SCHEMBL19964757 | 0.74 | LOXL2 (1.00) | LOXL2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | claimed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |