Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.56 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193947 | 0.81 | ALDH1A1 (0.59) | CYP2A6ALDH1A1ALOX15MAPK1MAPT | |
| SCHEMBL11785606 | 0.79 | ALDH1A1 (0.60) | LOXL2ALDH1A1ALOX15MAPK1MAPT | |
| SCHEMBL19953210 | 0.77 | CYP2A6 (0.46) | LOXL2CYP2A6ASIC3HPGD | |
| SCHEMBL26752820 | 0.73 | ALDH1A1 (0.49) | ALDH1A1ALOX15MAPK1MAPTHPGD | |
| SCHEMBL240588 | 0.72 | CYP2A6 (1.00) | LOXL2CYP2A6ASIC3AGXT | |
| SCHEMBL1194406 | 0.71 | ALDH1A1 (1.00) | ALDH1A1ALOX15MAPK1MAPTHPGD | |
| SCHEMBL7777304 | 0.71 | ALDH1A1 (0.60) | ALDH1A1ALOX15MAPK1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL6941951 | 0.71 | CYP2A6 (0.96) | LOXL2CYP2A6ASIC3AGXT | |
| SCHEMBL466086 | 0.71 | ALDH1A1 (1.00) | ALDH1A1ALOX15MAPK1MAPTHPGD | |
| Iodide SCHEMBL30536902 | 0.71 | CYP2A6 (0.96) | LOXL2CYP2A6ASIC3AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048928-A1 | CHEMICAL PROBES OF LYSYL OXIDASE-LIKE 2 AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |