Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960927 | 0.81 | KCNQ2 (0.44) | KCNQ2FABP5EPHX2HRH3HTR6 | |
| SCHEMBL19953533 | 0.80 | FABP5 (0.43) | FABP5EPHX2HRH3HTR6MTNR1A | |
| SCHEMBL19953489 | 0.80 | FABP5 (0.43) | FABP5EPHX2HRH3HTR6MTNR1A | |
| SCHEMBL19953584 | 0.80 | FABP5 (0.43) | FABP5EPHX2HRH3HTR6MTNR1A | |
| SCHEMBL28279788 | 0.77 | KDM4C (0.43) | KCNQ2HTR6MTNR1AMTNR1BTRPV1 | |
| SCHEMBL30899464 | 0.76 | KDM4C (0.44) | HTR6MTNR1AMTNR1BTRPV1KDM4C | |
| SCHEMBL16250257 | 0.76 | KDM4C (0.44) | HTR6MTNR1AMTNR1BTRPV1KDM4C | |
| SCHEMBL19127981 | 0.75 | KDM4C (0.42) | TRPV1KDM4CNPC1RAB9A | |
| SCHEMBL19953514 | 0.75 | OPRM1 (0.43) | KCNQ2FABP5EPHX2HRH3MTNR1A | |
| SCHEMBL20778981 | 0.75 | KDM4C (0.41) | HTR6MTNR1AMTNR1BTRPV1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | claimed |
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |