Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953491 | 1.00 | F11 (0.50) | F11ALDH1A1KMT2AHPGDNPSR1 | |
| SCHEMBL7344344 | 0.86 | ACE (0.50) | ALDH1A1KMT2AHPGDACEKDM4E | |
| SCHEMBL19953516 | 0.86 | F11 (0.53) | F11ALDH1A1NPSR1ACETSHR | |
| SCHEMBL19960667 | 0.86 | F11 (0.53) | F11ALDH1A1NPSR1ACETSHR | |
| SCHEMBL19953756 | 0.81 | F11 (0.48) | F11ALDH1A1NPSR1ACETSHR | |
| SCHEMBL19953529 | 0.80 | ACE (0.61) | F11ALDH1A1NPSR1ACETSHR | |
| SCHEMBL19953642 | 0.80 | ACE (0.61) | F11ALDH1A1NPSR1ACETSHR | |
| SCHEMBL14879169 | 0.80 | PRCP (0.51) | ALDH1A1KMT2AHPGDACEKDM4E | |
| SCHEMBL19960681 | 0.79 | F11 (0.55) | F11ALDH1A1NPSR1ACETSHR | |
| SCHEMBL7344341 | 0.77 | ACE (0.61) | ALDH1A1KMT2AACEKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |