Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.47 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960826 | 1.00 | ACE (0.47) | ACEGRM7NOTUMFFAR1HDAC4 | |
| SCHEMBL19953490 | 0.84 | ACE (0.46) | ACEGRM7 | |
| SCHEMBL19953697 | 0.84 | ACE (0.46) | ACEGRM7 | |
| SCHEMBL19953501 | 0.83 | GRM7 (0.61) | ACEGRM7FFAR1HDAC4HDAC7 | |
| SCHEMBL19953496 | 0.83 | GRM7 (0.61) | ACEGRM7FFAR1HDAC4HDAC7 | |
| SCHEMBL19953670 | 0.82 | ACE (0.42) | ACEGRM7 | |
| SCHEMBL20113077 | 0.81 | GRM7 (0.43) | ACEGRM7HDAC4HDAC7HDAC5 | |
| SCHEMBL19953523 | 0.81 | GRM7 (0.43) | ACEGRM7HDAC4HDAC7HDAC5 | |
| SCHEMBL19960658 | 0.81 | GRM7 (0.43) | ACEGRM7HDAC4HDAC7HDAC5 | |
| SCHEMBL19953664 | 0.80 | HRH3 (0.46) | GRM7MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |