Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 6/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960658 | 1.00 | GRM7 (0.43) | GRM7ACETOP1MEN1POLB | |
| SCHEMBL19953523 | 1.00 | GRM7 (0.43) | GRM7ACETOP1MEN1POLB | |
| SCHEMBL19960858 | 0.88 | GRM7 (0.40) | GRM7ACETOP1KMT2AHTR2A | |
| SCHEMBL20166097 | 0.83 | GRM7 (0.39) | GRM7MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL19953701 | 0.81 | ACE (0.47) | GRM7ACEMTNR1AMTNR1BHDAC4 | |
| SCHEMBL19960826 | 0.81 | ACE (0.47) | GRM7ACEMTNR1AMTNR1BHDAC4 | |
| SCHEMBL19960407 | 0.81 | ACE (0.43) | GRM7ACEPOLBKMT2AALDH1A1 | |
| SCHEMBL19953670 | 0.81 | ACE (0.42) | GRM7ACEALDH1A1 | |
| SCHEMBL25625959 | 0.80 | GRM7 (0.37) | GRM7TOP1HTR2AHRH1MTNR1A | |
| SCHEMBL19953490 | 0.80 | ACE (0.46) | GRM7ACEMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018079862-A1 | MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-03 | — | — | WO | disclosed |