Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953697 | 1.00 | ACE (0.46) | ACEMEN1APAF1ALDH1A1MAPT | |
| SCHEMBL19960922 | 0.89 | CYP2C9 (0.43) | ACEMEN1APAF1ALDH1A1MAPT | |
| SCHEMBL19960921 | 0.85 | GRM7 (0.42) | ACEMEN1APAF1ALDH1A1MAPT | |
| SCHEMBL19960826 | 0.84 | ACE (0.47) | ACEGRM7 | |
| SCHEMBL19953701 | 0.84 | ACE (0.47) | ACEGRM7 | |
| SCHEMBL19953623 | 0.82 | L3MBTL1 (0.46) | ACEMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL19953612 | 0.82 | L3MBTL1 (0.46) | ACEMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL19953501 | 0.82 | GRM7 (0.61) | ACEGRM7OPRM1OPRK1OPRL1 | |
| SCHEMBL19953496 | 0.82 | GRM7 (0.61) | ACEGRM7OPRM1OPRK1OPRL1 | |
| SCHEMBL19960658 | 0.80 | GRM7 (0.43) | ACEMEN1ALDH1A1KMT2AGRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |