SCHEMBL19953764

SCHEMBL19953764

c1ccc2nc(CNC3CC3)ccc2c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.60
MAOA P21397 1/20 0.60
MAOB P27338 1/20 0.60
CYP1A2 P05177 2/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
HDAC1 Q13547 3/20 0.44
HDAC2 Q92769 3/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
CYSLTR2 Q9NS75 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30022074 0.92 KDM1A (0.56) KDM1AMAOAMAOBCYP1A2CYP3A4
SCHEMBL19656391 0.92 KDM1A (0.56) KDM1AMAOAMAOBCYP1A2CYP3A4
SCHEMBL31428579 0.89 KDM1A (0.53) KDM1AMAOAMAOBCYP1A2CYP3A4
SCHEMBL2092750 0.85 KDM1A (0.52) KDM1AMAOAMAOBCYP1A2CYP3A4
SCHEMBL13448854 0.83 KDM1A (0.65) KDM1AMAOAMAOBCYP1A2CYP3A4
Hydrochloric Acid SCHEMBL27632631 0.79 MCHR1 (0.48) KDM1AMAOAMAOBCYP3A4HDAC1
Hydrochloric Acid SCHEMBL27632629 0.79 MCHR1 (0.48) KDM1AMAOAMAOBCYP3A4HDAC1
SCHEMBL24943587 0.77 HDAC1 (0.55) KDM1AMAOAMAOBCYP1A2HDAC1
Hydrochloric Acid SCHEMBL6927696 0.77 KDM1A (0.45) KDM1AMAOAMAOBHDAC1HDAC2
SCHEMBL4034649 0.76 SIGMAR1 (0.51) KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3509627-A1 LYSINE SPECIFIC HISTONE DEMETHYLASE-1 INHIBITORS AND USES THEREFOR University of Canberra (AU) 2019-07-17 EP disclosed
WO-2018045422-A1 LYSINE SPECIFIC HISTONE DEMETHYLASE-1 INHIBITORS AND USES THEREFOR UNIVERSITY OF CANBERRA (AU) 2018-03-15 WO disclosed