Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623603 | 1.00 | LMNA (0.46) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13610749 | 1.00 | LMNA (0.46) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13435075 | 1.00 | LMNA (0.46) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL26320640 | 0.83 | LMNA (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL20668731 | 0.83 | LMNA (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL9467302 | 0.83 | LMNA (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13003005 | 0.83 | LMNA (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL4384095 | 0.81 | LMNA (0.49) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL14473415 | 0.79 | SLC28A1 (0.44) | SLC29A1P2RY2P2RY12 | |
| SCHEMBL19953835 | 0.79 | SLC28A1 (0.44) | SLC29A1P2RY2P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914924-B2 | Methods and compositions for treating neurological disease | UNIVERSITY OF MASSACHUSETTS (US) | 2018-03-13 | — | — | US | disclosed |