Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.41 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.40 |
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845632 | 0.87 | LMNA (0.54) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL9467302 | 0.86 | LMNA (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL20668731 | 0.86 | LMNA (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13003005 | 0.86 | LMNA (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL26320640 | 0.86 | LMNA (0.63) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL24353169 | 0.86 | LMNA (0.47) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL20668750 | 0.85 | TSHR (0.46) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13623603 | 0.81 | LMNA (0.46) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13610749 | 0.81 | LMNA (0.46) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL19953828 | 0.81 | LMNA (0.46) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124555-A2 | NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION | Merck & Co., Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008085508-A2 | NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |