Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.71 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.71 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.63 |
| ▸ | IL1B | P01584 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19954315 | 1.00 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL3651900 | 1.00 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL23979591 | 0.93 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL26192402 | 0.91 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL22667820 | 0.91 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL3654670 | 0.91 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| Hydrochloric Acid SCHEMBL18815281 | 0.90 | CRBN (0.70) | CRBNDDB1IKZF3TNFIL1B | |
| Hydrochloric Acid SCHEMBL18815280 | 0.89 | CRBN (0.69) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL3653462 | 0.88 | CRBN (0.74) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL3653177 | 0.86 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200360382-A1 | 3-(SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | DEUTERX, LLC | 2020-11-19 | — | — | US | disclosed |
| US-10555946-B2 | 3-(substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same | DEUTERX, LLC (US) | 2020-02-11 | — | — | US | disclosed |
| US-9913845-B2 | 3-(substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same | DEUTERX, LLC (US) | 2018-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10555946-B2 | 3-(substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same | AQP3, AQP4, AQP1 | CRBN 2849/4885DDB1 3771/4885IKZF3 376/4885 |
| US-20200360382-A1 | 3-(SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | AQP3, AQP4, AQP1 | CRBN 2849/4885DDB1 3771/4885IKZF3 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.