Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 5/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21303814 | 0.89 | PAX8 (0.46) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL24253327 | 0.87 | PSMB5 (0.46) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL24253325 | 0.87 | PSMB5 (0.46) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL23334290 | 0.87 | PSMB5 (0.46) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL21303829 | 0.87 | PAX8 (0.46) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL22221603 | 0.87 | PAX8 (0.46) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL17693759 | 0.87 | PAX8 (0.46) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL21303828 | 0.86 | PAX8 (0.46) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL22851690 | 0.85 | CARM1 (0.41) | PAX8HSP90AA1CARM1NOS2PSMB5 | |
| SCHEMBL25179856 | 0.85 | PAX8 (0.45) | PAX8HSP90AA1CARM1NOS2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9913834-B2 | Bis-benzylidine piperidone proteasome inhibitor with anticancer activity | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-03-13 | — | — | US | disclosed |