Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | CARM1 | Q86X55 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253327 | 1.00 | PSMB5 (0.46) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL23334290 | 1.00 | PSMB5 (0.46) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL22221603 | 0.90 | PAX8 (0.46) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL21303829 | 0.90 | PAX8 (0.46) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL17693759 | 0.90 | PAX8 (0.46) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL21311554 | 0.89 | NOS2 (0.47) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL21303814 | 0.88 | PAX8 (0.46) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL24253239 | 0.88 | NOS2 (0.46) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL21303828 | 0.87 | PAX8 (0.46) | PSMB5PAX8HSP90AA1NOS2CARM1 | |
| SCHEMBL19954680 | 0.87 | PAX8 (0.44) | PSMB5PAX8HSP90AA1NOS2CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220048942-A1 | DOT1L DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220048942-A1 | DOT1L DEGRADERS AND USES THEREOF | ADRM1, PSME3, STUB1 | PSMB5 84/4885PAX8 3595/4885HSP90AA1 1751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.