Combretastatin

Combretastatin

SCHEMBL19955

COc1ccc(C[C@@H](O)c2cc(OC)c(OC)c(OC)c2)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB1 Q9H4B7 10/20 1.00
TUBB4A P04350 9/20 1.00
TUBB P07437 9/20 1.00
TUBA3C P0DPH7 9/20 1.00
TUBA1B P68363 9/20 1.00
TUBA4A P68366 9/20 1.00
TUBB4B P68371 9/20 1.00
TUBB3 Q13509 9/20 1.00
TUBB2A Q13885 9/20 1.00
TUBB8 Q3ZCM7 9/20 1.00
TUBA3E Q6PEY2 9/20 1.00
TUBA1A Q71U36 9/20 1.00
TUBA1C Q9BQE3 9/20 1.00
TUBB6 Q9BUF5 9/20 1.00
TUBB2B Q9BVA1 9/20 1.00
ALOX15 P16050 1/20 0.62
ALOX12 P18054 1/20 0.62
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
TSHR P16473 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Combretastatin SCHEMBL30334938 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL29356562 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL5566666 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL29394501 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL19956 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429578 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6430099 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6430650 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429581 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429821 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 21676 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122056826-A Drug-loaded magnesium-copper alginate hydrogel and preparation method and application thereof 荆楚理工学院 2026-05-19 CN claimed
EP-3730131-B1 TREATMENT OF BRAIN CANCER BY CONTINUOUS INFUSION OF COENZYME Q10 BPGBIO INC (US) 2026-04-22 EP claimed
US-12595232-B2 DRG-MDM2-1 for use as a novel Mouse Double Minute 2 (MDM2) inhibitor BAHCESEHIR UNIVERSITESI (TR) 2026-04-07 US claimed
US-12534571-B2 Amphiphilic block copolymer, preparation method thereof and nanomicelle drug-loading system SHANGHAI BEST-LINK BIOSCIENCE, LLC (CN) 2026-01-27 US claimed
EP-4676543-A1 METHODS OF TREATING CANCER USING ANTI-HER2 ANTIBODY-DRUG CONJUGATES AND HER2 KINASE INHIBITORS Seagen Inc. (US) 2026-01-14 EP claimed
US-20250387499-A1 LIGAND-PAYLOAD CONJUGATES PYXIS ONCOLOGY, INC. (US) 2025-12-25 US claimed
US-12502392-B2 DRG-MDM2-6 for use as a novel mouse double minute 2 (MDM2) inhibitor BAHCESEHIR UNIVERSITESI (TR) 2025-12-23 US claimed
US-12466893-B2 Antigen binding proteins GLAXO GROUP LIMITED (GB) 2025-11-11 US claimed
EP-4448107-B1 DRUG DELIVERY SYSTEMS BASED ON ENDOPEROXIDES USEFUL IN DIAGNOSIS AND THERAPY, AND METHODS THEREOF FACULDADE DE FARMACIA DA UNIV DE LISBOA (PT) 2025-11-05 EP claimed
EP-4642484-A1 TARGETED TREATMENT OF PROSTATE CANCERS AND OTHER TUMORS BY AN ANTIBODY-DRUG CONJUGATE Hangzhou Seehe Biotechnology Co., Ltd (CN) 2025-11-05 EP claimed
WO-2001060351-A2 NITROACRIDINE/TUMOR INHIBITOR COMPOSITIONS NEW YORK MEDICAL COLLEGE (US) 2001-08-23 WO claimed
WO-2000033888-A9 PRODRUG COMPOUNDS AND PROCESS FOR PREPARATION THEREOF COULTER PHARM INC (US) 2001-05-10 WO claimed
WO-2001018013-A1 PRODRUGS FOR LIVER SPECIFIC DRUG DELIVERY METABASIS THERAPEUTICS, INC. (US) 2001-03-15 WO claimed
US-6153655-A Terminally-branched polymeric linkers and polymeric conjugates containing the same ENZON, INC. (US) 2000-11-28 US claimed
WO-2000064946-A2 COMPOSITIONS AND METHODS FOR CANCER TREATMENT BY SELECTIVELY INHIBITING VEGF BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2000-11-02 WO claimed
WO-2000035865-A2 TUBULIN-BINDING AGENTS TULARIK INC. (US) 2000-06-22 WO claimed
WO-2000033888-A2 PRODRUG COMPOUNDS AND PROCESS FOR PREPARATION THEREOF COULTER PHARMACEUTICAL, INC. (US) 2000-06-15 WO claimed
US-6011042-A POLYMERIC PRODRUGS ARE PREFERABLY ESTERS OF HYDROXYL-CONTAINING AROMATIC COMPOUNDS AND ARE FORMED BY REACTING A DESIRED AROMATIC, HYDROXYL-CONTAINING COMPOUND WITH A SUBSTANTIALLY NON-ANTIGENIC POLYMER ENZON, INC. (US) 2000-01-04 US claimed
WO-1994005682-A1 COMBRETASTATIN DERIVATIVES WITH ANTITUMORAL ACTIVITY AND PROCESS FOR THE PREPARATION THEREOF PELIZZONI FRANCESCA (IT) 1994-03-17 WO claimed
WO-1992016486-A1 SUBSTITUTED DIPHENYLETHYLENES AND ANALOGUES OR DERIVATIVES THEREOF ASTON MOLECULES LIMITED (GB) 1992-10-01 WO claimed