Combretastatin

Combretastatin

SCHEMBL29356562

COc1ccc(C[C@H](O)c2cc(OC)c(OC)c(OC)c2)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB1 Q9H4B7 10/20 1.00
TUBB4A P04350 9/20 1.00
TUBB P07437 9/20 1.00
TUBA3C P0DPH7 9/20 1.00
TUBA1B P68363 9/20 1.00
TUBA4A P68366 9/20 1.00
TUBB4B P68371 9/20 1.00
TUBB3 Q13509 9/20 1.00
TUBB2A Q13885 9/20 1.00
TUBB8 Q3ZCM7 9/20 1.00
TUBA3E Q6PEY2 9/20 1.00
TUBA1A Q71U36 9/20 1.00
TUBA1C Q9BQE3 9/20 1.00
TUBB6 Q9BUF5 9/20 1.00
TUBB2B Q9BVA1 9/20 1.00
ALOX15 P16050 1/20 0.62
ALOX12 P18054 1/20 0.62
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
TSHR P16473 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Combretastatin SCHEMBL19955 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL30334938 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL5566666 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL29394501 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL19956 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429578 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6430099 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6430650 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429581 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429821 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 447 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260048022-A1 ENDOTHELIAL DAMAGE AND NANOPARTICLE TARGETING: COMPOSITIONS, PROCESSES, USES NANOPROBES INC (US) 2026-02-19 US claimed
EP-4313156-B1 DISULFIDE-BASED PRODRUG COMPOUNDS UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) 2025-08-06 EP claimed
EP-4525834-A1 ENDOTHELIAL DAMAGE AND NANOPARTICLE TARGETING: COMPOSITIONS, PROCESSES, USES Nanoprobes, Inc. (US) 2025-03-26 EP claimed
CN-118845653-A PH response type polylysine derivative nano micelle carrier and preparation method and application thereof 安徽中医药大学 2024-10-29 CN claimed
CN-118576550-A Calcium carbonate nanoparticle with tumor immune suppression reversing microenvironment and preparation method and application thereof 广州医科大学 2024-09-03 CN claimed
US-20240285971-A1 Intratumoral Alpha-Emitter Radiation in Combination with Vasculature Inhibitors ALPHA TAU MEDICAL LTD. (IL) 2024-08-29 US claimed
US-20240207414-A1 DISULFIDE-BASED PRODRUG COMPOUND LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) 2024-06-27 US claimed
US-20240156965-A1 DICHALCOGENIDE PRODRUGS LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) 2024-05-16 US claimed
EP-4359071-A1 INTRATUMORAL ALPHA-EMITTER RADIATION IN COMBINATION WITH VASCULATURE INHIBITORS Alpha Tau Medical Ltd. (IL) 2024-05-01 EP claimed
US-20240130982-A1 TREATMENT OF AVASCULAR OR HYPOVASCULAR MICRO-TUMORS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2024-04-25 US claimed
CN-117056966-A System for analyzing consistency of applet privacy policy and authority call 西安电子科技大学 2023-11-14 CN claimed
WO-2022269445-A1 INTRATUMORAL ALPHA-EMITTER RADIATION IN COMBINATION WITH VASCULATURE INHIBITORS ALPHA TAU MEDICAL LTD. (IL) 2022-12-29 WO claimed
CN-111603436-B Photodynamic silica nanomaterial @ hydrogel composite drug loading system, and preparation method and application thereof 徐州医科大学 2022-12-27 CN claimed
US-20220401556-A1 USE OF VDAS TO ENHANCE IMMUNOMODULATING THERAPIES AGAINST TUMORS ONCOTELIC THERAPEUTICS, INC. 2022-12-22 US claimed
WO-2022214598-A1 DICHALCOGENIDE PRODRUGS LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2022-10-13 WO claimed
EP-4071148-A1 DICHALCOGENIDE PRODRUGS Ludwig-Maximilians-Universität München (DE) 2022-10-12 EP claimed
WO-2022200347-A1 DISULFIDE-BASED PRODRUG COMPOUNDS LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2022-09-29 WO claimed
EP-4062942-A1 DISULFIDE-BASED PRODRUG COMPOUNDS Ludwig-Maximilians-Universität München (DE) 2022-09-28 EP claimed
US-11419934-B2 Use of VDAS to enhance immunomodulating therapies against tumors ONCOTELIC THERAPEUTICS, INC. (US) 2022-08-23 US claimed
CN-110672745-B Method for measuring combretastatin and metabolites thereof 复旦大学附属肿瘤医院 2022-03-18 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260048022-A1 ENDOTHELIAL DAMAGE AND NANOPARTICLE TARGETING: COMPOSITIONS, PROCESSES, USES VEGFA, FLT1, FLT4 TUBB1 904/4885TUBB4A 948/4885TUBB 1057/4885
US-20220401556-A1 USE OF VDAS TO ENHANCE IMMUNOMODULATING THERAPIES AGAINST TUMORS CD274, PDCD1LG2, PDCD1 TUBB1 3110/4885TUBB4A 1043/4885TUBB 3743/4885
US-20240207414-A1 DISULFIDE-BASED PRODRUG COMPOUND CBS, MSR1, P4HB TUBB1 2263/4885TUBB4A 2646/4885TUBB 2338/4885
US-20240156965-A1 DICHALCOGENIDE PRODRUGS DHCR7, DECR1, CYP27A1 TUBB1 3482/4885TUBB4A 2635/4885TUBB 3289/4885
US-11419934-B2 Use of VDAS to enhance immunomodulating therapies against tumors CD274, PDCD1LG2, CA4 TUBB1 2952/4885TUBB4A 999/4885TUBB 3646/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.