Combretastatin

Combretastatin

SCHEMBL29394501

COc1ccc(C[C@@H](O)c2cc(OC)c(OC)c(OC)c2)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB1 Q9H4B7 10/20 1.00
▸ TUBB4A P04350 9/20 1.00
▸ TUBB P07437 9/20 1.00
▸ TUBA3C P0DPH7 9/20 1.00
▸ TUBA1B P68363 9/20 1.00
▸ TUBA4A P68366 9/20 1.00
▸ TUBB4B P68371 9/20 1.00
▸ TUBB3 Q13509 9/20 1.00
▸ TUBB2A Q13885 9/20 1.00
▸ TUBB8 Q3ZCM7 9/20 1.00
▸ TUBA3E Q6PEY2 9/20 1.00
▸ TUBA1A Q71U36 9/20 1.00
▸ TUBA1C Q9BQE3 9/20 1.00
▸ TUBB6 Q9BUF5 9/20 1.00
▸ TUBB2B Q9BVA1 9/20 1.00
▸ ALOX15 P16050 1/20 0.62
▸ ALOX12 P18054 1/20 0.62
▸ CYP1A2 P05177 1/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ TSHR P16473 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Combretastatin SCHEMBL30334938 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL29356562 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL19955 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL19956 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL5566666 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6430099 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429581 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6430650 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429578 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Combretastatin SCHEMBL6429821 0.98 TUBB1 (0.97) TUBB1TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3868409-B1 THIOPHENOL-MALEIMIDE AND BROM-MALEIMIDE DERIVATIVES AS LINKER FOR ANTIBODY-DRUG CONJUGATES (ADC) FOR TREATING TUMORS REMEGEN CO LTD (CN) 2024-07-17 — — EP claimed
EP-4110405-A1 ANTI-CD56 ANTIBODY-DRUG CONJUGATES AND THEIR USE IN THERAPY MCSAF INSIDE ONOCOLOGY (FR) 2023-01-04 — — EP claimed
EP-3972652-A1 ANTIBODY-DRUG CONJUGATES AND THEIR USE IN THERAPY Mc SAF (FR) 2022-03-30 — — EP claimed
EP-4682148-A2 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES AbbVie Ireland Unlimited Company (IE) 2026-01-21 — — EP disclosed
US-20260007755-A1 SELF-ASSEMBLED DIBLOCK COPOLYMERS COMPOSED OF PEGMEMA AND DRUG BEARING POLYMERIC SEGMENTS RS ARASTIRMA EGITIM DANISMANLIK ILAC SANAYI TICARET ANONIM SIRKETI (TR) 2026-01-08 — — US disclosed
WO-2025245128-A1 ANTIBODY DRUG CONJUGATES AND THERAPEUTIC USES THEREOF MYTHIC THERAPEUTICS, INC. (US) 2025-11-27 — — WO disclosed
EP-4401787-B1 VECTORS TARGETING BETA-D-N-ACETYLGLUCOSAMINIDASE CENTRE NAT RECH SCIENT (FR) 2025-11-05 — — EP disclosed
EP-4630456-A1 ANTI-CMET ANTIBODY DRUG CONJUGATES AND THERAPEUTIC USES THEREOF Mythic Therapeutics, Inc. (US) 2025-10-15 — — EP disclosed
US-20250223554-A1 METHODS AND COMPOSITIONS USING RECOMBINANT DENDRITIC CELLS FOR CANCER THERAPY RENOVARO BIOPHARMA INC. 2025-07-10 — — US disclosed
WO-2025137441-A1 RADIOPHARMACEUTICALS TARGETING SOMATOSTATIN RECEPTOR 2 AND USES THEREOF RAYZEBIO, INC. (US) 2025-06-26 — — WO disclosed
US-20250145587-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2025-05-08 — — US disclosed
US-11352369-B2 Pyridine and pyrimidine derivatives ASTRAZENECA AB (SE) 2022-06-07 — — US disclosed
EP-4003428-A1 ANTIBODY-POLYMER-CONJUGATES Bogazici Universitesi (TR) 2022-06-01 — — EP disclosed
US-20220152216-A1 ANTIBODY-POLYMER CONJUGATES BOGAZICI UNIVERSITESI (TR) 2022-05-19 — — US disclosed
US-20220127308-A1 Desmoglein 2 (DSG2) Binding Proteins and Uses Therefor UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION 2022-04-28 — — US disclosed
US-11311625-B2 Peptide-based multiple-drug delivery vehicle ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) 2022-04-26 — — US disclosed
US-11291630-B2 Gelling compositions for treating malignant tumours and/or preventing tumour recurrence CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) 2022-04-05 — — US disclosed
EP-3972652-A1 ANTIBODY-DRUG CONJUGATES AND THEIR USE IN THERAPY Mc SAF (FR) 2022-03-30 — — EP disclosed
CN-114206885-A Pyrazolo [3,4-B ] pyrazine SHP2 phosphatase inhibitors 大冢制药株式会社 2022-03-18 — — CN disclosed
US-11248028-B2 Desmoglein 2 (DSG2) binding proteins and uses therefor UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) 2022-02-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260007755-A1 SELF-ASSEMBLED DIBLOCK COPOLYMERS COMPOSED OF PEGMEMA AND DRUG BEARING POLYMERIC SEGMENTS CLTB, F13B, FGB TUBB1 231/4885TUBB4A 310/4885TUBB 178/4885
US-11311625-B2 Peptide-based multiple-drug delivery vehicle VIP, NGLY1, IAPP TUBB1 1753/4885TUBB4A 1770/4885TUBB 1357/4885
US-20220152216-A1 ANTIBODY-POLYMER CONJUGATES CD44, FCGR1A, FCGR2A TUBB1 479/4885TUBB4A 491/4885TUBB 650/4885
US-11352369-B2 Pyridine and pyrimidine derivatives CDK9, BCL9, CDK19 TUBB1 2062/4885TUBB4A 1658/4885TUBB 1741/4885
US-20250145587-A1 BROMODOMAIN INHIBITORS BRD4, BRD3, BRD1 TUBB1 621/4885TUBB4A 982/4885TUBB 871/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback