Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18944215 | 0.91 | NR1I2 (0.36) | NR1I2KLKB1ALDH1A1 | |
| SCHEMBL19955759 | 0.88 | NR1I2 (0.38) | NR1I2MEN1ALDH1A1GAAMAPT | |
| SCHEMBL18929663 | 0.86 | NR1I2 (0.35) | NR1I2MEN1ALDH1A1GAAMAPT | |
| SCHEMBL19955789 | 0.85 | NR1I2 (0.37) | NR1I2MAPT | |
| SCHEMBL19955514 | 0.85 | NR1I2 (0.38) | NR1I2MAPT | |
| SCHEMBL18664243 | 0.83 | NR1I2 (0.36) | NR1I2MEN1ALDH1A1GAAMAPT | |
| SCHEMBL19955743 | 0.80 | NR1I2 (0.36) | NR1I2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL18928959 | 0.80 | NR1I2 (0.33) | NR1I2 | |
| SCHEMBL19955744 | 0.79 | NR1I2 (0.33) | NR1I2 | |
| SCHEMBL19955611 | 0.77 | NR1I2 (0.41) | NR1I2MEN1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166925-B1 | ISOINDOLINE DERIVATIVES FOR USE IN THE TREATMENT OF A VIRAL INFECTION | VIIV HEALTHCARE UK LTD (GB) | 2018-03-14 | — | — | EP | disclosed |