Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ESR1 | P03372 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1301779 | 0.88 | NOX4 (0.75) | NOX4MAPTESR1KMT2AHPGD | |
| SCHEMBL1302708 | 0.77 | NOX4 (0.75) | NOX4MAPTESR1KMT2AHPGD | |
| SCHEMBL1302975 | 0.77 | NOX4 (0.72) | NOX4MAPTESR1KMT2AHPGD | |
| SCHEMBL1303369 | 0.74 | NOX4 (0.87) | NOX4MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL1303727 | 0.73 | NOX4 (1.00) | NOX4ALDH1A1CYP3A4 | |
| SCHEMBL1302658 | 0.70 | NOX4 (0.80) | NOX4ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL1303656 | 0.69 | NOX4 (0.65) | NOX4MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1302585 | 0.69 | NOX4 (0.70) | NOX4MAPTKMT2ASMN1; SMN2CYP3A4 | |
| SCHEMBL4023307 | 0.67 | MAPT (0.57) | NOX4MAPTKMT2AHPGDSMN1; SMN2 | |
| Dodecane SCHEMBL11373218 | 0.65 | MAPT (0.48) | NOX4MAPTKMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860179-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SUISSE SA (CH) | 2018-03-14 | — | — | EP | disclosed |