Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 6/20 | 0.57 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302281 | 0.97 | NOX4 (0.60) | NOX4KLKB1KLK1PDE10AGRM2 | |
| SCHEMBL1302880 | 0.92 | NOX4 (0.50) | NOX4PDE10A | |
| SCHEMBL1302459 | 0.78 | NOX4 (0.43) | NOX4KDM4EUSP2ALDH1A1CYP1A2 | |
| SCHEMBL1302694 | 0.78 | MEN1 (0.44) | NOX4KDM4EUSP2ALDH1A1TSHR | |
| SCHEMBL1302224 | 0.77 | NOX4 (0.45) | NOX4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2217002 | 0.75 | NOX4 (0.56) | NOX4KLKB1KLK1PIK3CDPIK3CB | |
| SCHEMBL1302839 | 0.75 | NOX4 (0.78) | NOX4KLKB1KLK1 | |
| SCHEMBL2212598 | 0.74 | NOX4 (0.73) | NOX4KDM4EALDH1A1CASP1CASP7 | |
| SCHEMBL1302859 | 0.74 | PDE4B (0.48) | NOX4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL16638872 | 0.74 | NOX4 (0.44) | NOX4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860179-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SUISSE SA (CH) | 2018-03-14 | — | — | EP | disclosed |