Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 12/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4323763 | 0.75 | SPHK1 (0.61) | SPHK1SPHK2 | |
| SCHEMBL9346694 | 0.74 | SPHK1 (0.53) | SPHK1ALDH1A1LMNAMAPTCYP2C9 | |
| SCHEMBL9359614 | 0.73 | CYP2C9 (0.49) | SPHK1ALDH1A1LMNAMAPTCYP2C9 | |
| SCHEMBL10486078 | 0.73 | CYP2C9 (0.58) | SPHK1ALDH1A1LMNAMAPTCYP2C9 | |
| SCHEMBL11466853 | 0.73 | CYP2C9 (0.58) | SPHK1ALDH1A1LMNAMAPTCYP2C9 | |
| SCHEMBL11466923 | 0.73 | CYP2C9 (0.58) | SPHK1ALDH1A1LMNAMAPTCYP2C9 | |
| SCHEMBL19956743 | 0.72 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCYP2C9 | |
| SCHEMBL8680778 | 0.72 | SPHK1 (0.48) | SPHK1ALDH1A1LMNAMAPTCYP2C9 | |
| SCHEMBL11280039 | 0.71 | SPHK1 (0.44) | SPHK1ALDH1A1LMNAMAPTCYP2C9 | |
| SCHEMBL11895195 | 0.71 | ESR2 (0.61) | SPHK1CYP2C9SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805951-B1 | Inhibitors of diacylglycerol o-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS INC (US) | 2018-03-14 | — | — | EP | disclosed |