Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | NOS2 | P35228 | 7/20 | 0.61 |
| ▸ | NOS1 | P29475 | 6/20 | 0.61 |
| ▸ | NOS3 | P29474 | 4/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.47 |
| ▸ | PHGDH | O43175 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830500 | 0.88 | KDM4E (0.71) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL827883 | 0.85 | ALDH1A1 (0.83) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL15830498 | 0.82 | ALDH1A1 (0.90) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL13922609 | 0.82 | KDM4E (0.97) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL15829837 | 0.82 | KDM4E (0.63) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL13922608 | 0.81 | KDM4E (1.00) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL15829843 | 0.80 | NOS2 (0.73) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL15829838 | 0.80 | KDM4E (0.61) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL7698244 | 0.78 | ALDH1A1 (0.71) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 | |
| SCHEMBL828268 | 0.78 | ALDH1A1 (0.71) | ALDH1A1KDM4EL3MBTL1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935247-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2019-08-28 | — | — | EP | disclosed |
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |