Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15882239 | 0.75 | HRH4 (0.44) | HRH4CLK1DYRK1AMAPTROCK1 | |
| SCHEMBL4400860 | 0.75 | HRH4 (0.45) | HRH4PDE3BPDE3ACLK1DYRK1A | |
| SCHEMBL18130032 | 0.73 | KMT2A (0.42) | MAPTTP53 | |
| SCHEMBL24834492 | 0.72 | NOS3 (0.39) | ROCK1 | |
| SCHEMBL25158171 | 0.72 | DYRK1A (0.37) | DYRK1AMAPT | |
| SCHEMBL5935848 | 0.72 | HRH4 (0.41) | HRH4CLK1DYRK1ADRD2DRD3 | |
| SCHEMBL30828868 | 0.71 | HRH4 (0.57) | HRH4PDE3BPDE3ACLK1DYRK1A | |
| SCHEMBL3470490 | 0.71 | HRH4 (0.42) | HRH4PDE3BPDE3ACLK1DYRK1A | |
| SCHEMBL5275762 | 0.71 | HRH4 (0.42) | HRH4PDE3BPDE3ACLK1DYRK1A | |
| SCHEMBL12777861 | 0.71 | HRH4 (0.42) | HRH4PDE3BPDE3ACLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3885340-A1 | ANDROGEN RECEPTOR MODULATING COMPOUNDS | ORION CORPORATION (FI) | 2021-09-29 | — | — | EP | disclosed |
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |