Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6276392 | 0.75 | HRH4 (0.42) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL12777861 | 0.75 | HRH4 (0.42) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL4400860 | 0.75 | HRH4 (0.45) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL31361318 | 0.75 | HRH4 (0.39) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL9966056 | 0.75 | DRD2 (0.47) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL25246071 | 0.72 | HRH4 (0.40) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL22607307 | 0.71 | HRH4 (0.42) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL29493481 | 0.71 | HRH4 (0.39) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL11037075 | 0.71 | HRH4 (0.42) | HRH4DYRK1ACLK1DRD2DRD4 | |
| SCHEMBL12223303 | 0.71 | DRD2 (0.47) | HRH4DYRK1ACLK1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |