Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.42 |
| ▸ | IL1B | P01584 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363570 | 0.91 | SYK (0.45) | HRH4KAT2BJAK3JAK2SYK | |
| SCHEMBL13103494 | 0.84 | CCR6 (0.50) | HRH4RPS6KB1KAT2BIL1BNLRP3 | |
| SCHEMBL13700891 | 0.84 | CCR6 (0.50) | HRH4RPS6KB1KAT2BIL1BNLRP3 | |
| SCHEMBL28447539 | 0.80 | KAT2B (0.45) | HRH4RPS6KB1KAT2BCDK9CCNK | |
| SCHEMBL15247306 | 0.80 | HRH4 (0.43) | HRH4RPS6KB1KAT2BIL1BJAK3 | |
| SCHEMBL14147062 | 0.80 | HRH4 (0.43) | HRH4RPS6KB1KAT2BIL1BJAK3 | |
| SCHEMBL15722382 | 0.80 | HRH4 (0.48) | HRH4RPS6KB1KAT2BIL1BNLRP3 | |
| SCHEMBL27680946 | 0.79 | HCAR3 (0.56) | HCAR3CCNKCDK12 | |
| SCHEMBL2709790 | 0.79 | HCAR3 (0.56) | HCAR3CCNKCDK12 | |
| SCHEMBL21299823 | 0.77 | HRH4 (0.48) | HRH4RPS6KB1KAT2BIL1BNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |