Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 15/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15834735 | 0.96 | ACHE (0.49) | ACHEMAPK8CDC7MEN1USP2 | |
| SCHEMBL13779897 | 0.77 | HRH4 (0.53) | ACHEMAPK8CDC7 | |
| SCHEMBL15830012 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL28617770 | 0.73 | MALT1 (0.41) | MEN1USP2ALDH1A1TP53CYP1A2 | |
| SCHEMBL17303793 | 0.72 | ALDH1A1 (0.54) | ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL17300823 | 0.72 | PIK3CA (0.37) | MEN1ALDH1A1CYP1A2CYP2D6KMT2A | |
| SCHEMBL15830164 | 0.71 | ALDH1A1 (0.52) | ALDH1A1KMT2A | |
| SCHEMBL10274926 | 0.71 | ACHE (0.57) | ACHEMAPK8CDC7 | |
| SCHEMBL4039837 | 0.70 | ACHE (0.56) | ACHEMAPK8CDC7KMT2A | |
| SCHEMBL21064103 | 0.70 | ABL1 (0.38) | MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935247-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2019-08-28 | — | — | EP | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |