Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34474144 | 0.83 | HTR2C (0.47) | HTR2CUSP30HTR2BMEN1ALDH1A1 | |
| SCHEMBL17303503 | 0.82 | HTR2C (0.44) | HTR2CUSP30HTR2BSLC6A2SLC6A4 | |
| SCHEMBL17300864 | 0.81 | USP30 (0.43) | HTR2CUSP30HTR2BSLC6A2SLC6A4 | |
| SCHEMBL17308354 | 0.81 | USP30 (0.43) | HTR2CUSP30HTR2BSLC6A2SLC6A4 | |
| SCHEMBL19287840 | 0.79 | SLC6A2 (0.46) | HTR2CUSP30HTR2BSLC6A2SLC6A4 | |
| SCHEMBL29455234 | 0.78 | HTR2C (0.60) | HTR2CHTR2BMEN1KMT2AHTR2A | |
| SCHEMBL9833957 | 0.77 | HTR2C (0.48) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL21456816 | 0.76 | KMT2A (0.43) | USP30KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL21139642 | 0.74 | CCR5 (0.42) | HTR2CHTR2BKDM4EMEN1ALDH1A1 | |
| SCHEMBL3485687 | 0.71 | ALDH1A1 (0.71) | HTR2CKDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |