Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010417 | 0.85 | USP2 (0.67) | USP2ABCB1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL11825493 | 0.82 | GLA (0.68) | USP2ABCB1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2871937 | 0.80 | MAPT (0.62) | USP2ABCB1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL9221920 | 0.80 | L3MBTL1 (0.61) | SMN1; SMN2MAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL31607061 | 0.80 | TSHR (0.61) | SMN1; SMN2MAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL3259595 | 0.79 | USP2 (0.60) | USP2ABCB1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3154126 | 0.79 | L3MBTL1 (0.62) | USP2ABCB1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL20738265 | 0.79 | KDM4E (0.56) | SMN1; SMN2MAPTLMNAHPGDL3MBTL1 | |
| SCHEMBL5318188 | 0.79 | SMN1; SMN2 (0.64) | USP2ABCB1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL20150488 | 0.78 | ALDH1A1 (0.59) | USP2ABCB1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935247-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2019-08-28 | — | — | EP | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |