SCHEMBL1995933

SCHEMBL1995933

Nc1ccc(-c2nc3ccc(N)cc3s2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 1.00
KDM4E B2RXH2 6/20 1.00
GAA P10253 6/20 1.00
NPC1 O15118 5/20 1.00
RAB9A P51151 5/20 1.00
GLA P06280 4/20 1.00
APP P05067 12/20 0.81
SMN1; SMN2 Q16637 5/20 0.81
TP53 P04637 3/20 0.81
THRB P10828 1/20 0.81
ALDH1A1 P00352 4/20 0.81
HPGD P15428 3/20 0.81
MEN1 O00255 2/20 0.81
KMT2A Q03164 2/20 0.81
PKM P14618 2/20 0.81
POLB P06746 3/20 0.74
NFKB1 P19838 2/20 0.74
GFER P55789 2/20 0.74
NFKB2 Q00653 2/20 0.74
RELA Q04206 2/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6854930 0.98 MAPT (0.96) MAPTKDM4EGAANPC1RAB9A
SCHEMBL2628259 0.93 MAPT (0.86) MAPTKDM4EGAANPC1RAB9A
SCHEMBL31219254 0.90 APP (1.00) MAPTKDM4EGAANPC1RAB9A
SCHEMBL13806256 0.90 APP (1.00) MAPTKDM4EGAANPC1RAB9A
SCHEMBL3193978 0.90 MAPT (0.81) MAPTKDM4EGAANPC1RAB9A
SCHEMBL5906538 0.90 MAPT (1.00) MAPTKDM4EGAANPC1RAB9A
SCHEMBL3194266 0.89 MAPT (1.00) MAPTKDM4EGAANPC1RAB9A
SCHEMBL15496408 0.89 MAPT (0.79) MAPTKDM4EGAANPC1RAB9A
SCHEMBL2174265 0.88 MAPT (0.78) MAPTKDM4EGAANPC1RAB9A
SCHEMBL15510887 0.87 MAPT (0.77) MAPTKDM4EGAANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114261149-B Polyimide arc-proof clothing fabric and arc-proof clothing 江苏先诺新材料科技有限公司 2024-08-13 CN claimed
CN-114261149-A Polyimide arc-proof garment fabric and arc-proof garment 江苏先诺新材料科技有限公司 2022-04-01 CN claimed
CN-107778484-B A kind of polyimide hollow fiber and its preparation method and application 北京化工大学 2019-08-13 CN claimed
CN-106084222-A Intrinsical height heat conduction polyimides containing polyacetylene chain structure and preparation method 杭州福斯特光伏材料股份有限公司 2016-11-09 CN claimed
CN-114261149-B Polyimide arc-proof clothing fabric and arc-proof clothing 江苏先诺新材料科技有限公司 2024-08-13 CN disclosed
CN-114261149-A Polyimide arc-proof garment fabric and arc-proof garment 江苏先诺新材料科技有限公司 2022-04-01 CN disclosed
CN-106279684-A Polymer, method for preparing the same, and photosensitive resin composition comprising the same 财团法人工业技术研究院 2017-01-04 CN disclosed
CN-106133062-A Peel ply formation compositions 日产化学工业株式会社 2016-11-16 CN disclosed
CN-106084222-A Intrinsical height heat conduction polyimides containing polyacetylene chain structure and preparation method 杭州福斯特光伏材料股份有限公司 2016-11-09 CN disclosed
CN-104204037-B Polyamic acid and containing its resin combination 东丽株式会社 2016-08-24 CN disclosed
CN-101608122-B Liquid crystal aligning agent and liquid crystal display element JSR CORP 2013-11-06 CN disclosed
US-20110152246-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2011-06-23 US disclosed
US-4225492-A Water-soluble disazo dyestuffs, prepared from unsymmetrical heterocyclic diamines CASSELLA AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
US-4221709-A Azo pigments DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) 1980-09-09 US disclosed
US-4144231-A Soluble trisazo dyestuffs containing a 2-phenyl-benzimidazolyl, -benzoxazolyl or -benzthiazolyl middle component CASSELLA AKTIENGESELLSCHAFT (DE) 1979-03-13 US disclosed
US-4144230-A Soluble trisazo dyestuffs containing a 2-phenyl-benzimidazolyl, -benzoxazolyl or -benzthiazolyl middle component CASSELLA AKTIENGESELLSCHAFT (DE) 1979-03-13 US disclosed
US-4143033-A WATER-SOLUBLE DISAZO DYESTUFFS CONTAINING A 2-PHENYL-BENZIMIDAZOLYL,-BENZOXAZOLYL OR-BENZTHIAZOLYL MIDDLE COMPONENT CASSELLA AKTIENGESELLSCHAFT (DE) 1979-03-06 US disclosed
US-4137228-A HIGH TINCTORIAL STRENGTH, COLORFASTNESS CASSELLA AKTIENGESELLSCHAFT (DE) 1979-01-30 US disclosed
US-4033945-A Water-soluble trisazo 8-amino-naphthol-1 dyes CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1977-07-05 US disclosed
US-4024125-A Dis-azo pigments deriving from bis-diazotized diamino-2-phenyl-benzazolones HOECHST AKTIENGESELLSCHAFT (DT) 1977-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152246-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION EIF2AK2, HAVCR2, IRF3 MAPT 4399/4885KDM4E 450/4885GAA 1003/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.